A client has been given a prescription levodopa-Carbidopa (Sinemet) for his Parkinson’s disease. He has been on “plain levodopa” for several ycars. What is the best rationale for this change? Generally, the combination of the two medications allows dopamine to cross the blood brain barrier. Levodopa tends to have an autoinduction mechanism that requires higher and higher dosages when used alone. There are concerns about drug-food interactions with levodopa therapy that do not exist with the combination therapy. The combination keeps levodopa from being destroyed which allows more medication to get into the brain.
[Answered]: A client has been given a prescription…
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