[Verified Answer]: Case study: A 60-year-old male had a…

Case study: A 60-year-old male had a lifelong problem with abnormal bleeding and bruising. As a child he had frequent nosebleeds following minimal trauma, but these decreased somewhat as of recently. At the age of 30 he underwent full mouth extraction. Post-extraction he had severe bleeding problems despite being given Vit K immediately prior to extraction. The patient had received multiple transfusions in the past and was also anemic. Family history revealed the patient’s paternal grandmother was a “bleeder” and his father also had severe bleeding problems. One of the patient’s 2 sons had a history of unusual bleeding events as well. Laboratory results: PT 12 sec. PTT 48 sec. Bleeding time: 12 minutes Factor VIII antigen 0% Factor VIII functional 12% PTT corrected upon addition of absorbed plasma but not aged serum Platelet adhesion test: Normal Platelet Agg studies: Normal response with ADP and collagen; decreased response to Ristocetin Reference: Factors in absorbed plasma: V, VIII, XI and XIII Factors in aged serum: VII, IX, X, XI, and XII What is the likely diagnosis? What are 2 reasons that support the diagnosis?